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Featured Publications

2019 Publications

TB-CRE Investigator TB-related publications

Abdelghanya S, Parumasivam T, Roedinger B, Pang A, Tang P, Jahn K, Britton WJ, Chan H-K. Alginate modified-PLGA nanoparticles entrapping amikacin and moxifloxacin as a novel host-directed therapy for multidrug-resistant tuberculosis. J Drug Delivery Sci Tech 2019;52:642-651.

Aia P, Majumdar SS, Pomat W, Tefuarani N, Graham SM, Dakulala P. Building operational research capacity for tuberculosis in Papua New Guinea.  Public Health Action2019; 9 (Suppl 1): S1-S2

Akkerman O, Aleksa A, Alffenaar JW, Al-Marzouqi NH, Arias-Guillén M, Belilovski E … Denholm J et al; members of the International Study Group on new anti-tuberculosis drugs and adverse events monitoring. Surveillance of adverse events in the treatment of drug-resistant tuberculosis: A global feasibility study. Int J Infect Dis 2019;83:72-76. doi: 10.1016/j.ijid.2019.03.036.

Al Yazidi LS, Marais BJ, Wickens M, Palasanthiran P, Isaacs D, Outhred A, McMullan B, Britton PN. Overview of paediatric Tuberculosis cases treated in the Sydney Children's Hospitals Network, Australia. Public Health Res Pract 2019;29(2). pii: 282318076. doi: 10.17061/phrp28231807


Alene KA, Viney K, Gray DJ, McBryde ES, Wagnew M, Clements ACA. Mapping Tuberculosis treatment outcomes in Ethiopia. BMC Infect Dis 2019;19(1):474. doi: 10.1186/s12879-019-4099-8.

Alene KA, Viney K, McBryde ES, Gray DJ, Melku M, Clements ACA. Risk factors for multidrug-resistant Tuberculosis in northwest Ethiopia: A case-control study. Transbound Emerg Dis 2019;66(4):1611-1618. doi: 10.1111/tbed.13188

Alffenaar JC, Sintchenko V, Marais BJ. Acquired Drug Resistance: Recognizing the Potential of Repurposed Drugs. Clin Infect Dis 2019. pii: ciz334. doi: 10.1093/cid/ciz334.

Ali SM, Anjum N, Ishaq M, Naureen F, Noor A, Rashid A, Abbas SM, Viney K. Community knowledge about tuberculosis and perception about tuberculosis associated stigma in Pakistan. Societies 2019;9(1):9.

Apis V, Landi M, Graham SM, Islam T, Amini J, Sabumi G, Mandalakas AM, Meae T, du Cros P, Shewade HD, Welch H. Outcomes in children treated for tuberculosis with the new dispersible fixed-dose combinations in Port Moresby.  Public Health Action 2019; 9 (Suppl 1): S32-S37

Ashhurst AS, Flόrido M, Lin LCW, Quan D, Armitage E, Stifter SA, Stambas J, Britton WJ. CXCR6-Deficiency Improves the Control of Pulmonary Mycobacterium tuberculosis and Influenza Infection Independent of T-Lymphocyte Recruitment to the Lungs. Front Immunol 2019; doi: 10.3389/fimmu.2019.00339

Ashhurst AS, McDonald DM, Hanna CC, Stanojevic VA, Britton WJ, Payne RJ. Mucosal Vaccination with a Self-Adjuvanted Lipopeptide Is Immunogenic and Protective against Mycobacterium tuberculosis. J Med Chem 2019;62(17):8080-8089. doi: 10.1021/acs.jmedchem.9b00832

Bainomugisa A, Pandey S, Donnan E, Simpson G, Foster J, Lavu E, Hiasihri S, McBryde ES, Moke R, Vincent S, Sintchenko V, Marais BJ, Coin LJM, Coulter C. Cross-Border Movement of Highly Drug-Resistant Mycobacterium tuberculosis from Papua New Guinea to Australia through Torres Strait Protected Zone, 2010-2015. Emerg Infect Dis 2019;25(3):406-415. doi: 10.3201/eid2503.181003.

Banamu JK, Lavu E, Johnson K, Moke R, Majumdar SS, Takarinda KC, Commons RJ. Impact of GxAlert on the management of rifampicin-resistant tuberculosis patients, Port Moresby, Papua New Guinea. Pub Health Act 2019; 9(Supplement 1):S19-S24

Birungi FM, Graham SM, Uwimana J, Musabimana A, van Wyk B. Adherence to isoniazid preventive therapy among child contacts in Rwanda: A mixed-methods study. PLoS One 2019;14(2):e0211934. doi: 10.1371/journal.pone.0211934. eCollection 2019.

Black HD, Xu W, Hortle E, Robertson SI, Britton WJ, Kaur A, New EJ, Witting PK, Chami B, Oehlers S. The cyclic nitroxide antioxidant 4-methoxy-TEMPO decreases mycobacterial burden in vivo through host and bacterial targets. Free Radic Biol Med 2019;135:157-166. doi: 10.1016/j.freeradbiomed.2019.03.010

Borisov SE, D'Ambrosio L, Centis R, Tiberi S, Dheda K, Alffenaar JW, Amale R, Belilowski E, Bruchfeld J, Canneto B, Denholm J et al. Outcomes of patients with drug-resistant-tuberculosis treated with bedaquiline-containing regimens and undergoing adjunctive surgery. J Infect 2019;78:35-39. doi: 10.1016/j.jinf.2018.08.003. Epub 2018 Aug 7.

Byrne AL, Marais BJ, Mitnick CD, Garden FL, Lecca L, Contreras C, Yauri Y, Garcia F, Marks GB. Asthma and atopy prevalence are not reduced among former Tuberculosis patients compared with controls in Lima, Peru. BMC Pulm Med 2019;19(1):40. doi: 10.1186/s12890-019-0804-z

Chang RYC, Wallin M, Kutter E, Morales S, Britton WJ, Li J, Chan HK. Storage stability of inhalable phage powders containing lactose at ambient conditions. Int J Pharmaceutics 2019

Cheung YM, Van K, Lan L, Barmanray R, Qian SY, Shi WY, Wong JLA, Hamblin PS, Colman PG, Topliss DJ, Denholm JT, Grossmann M. Hypothyroidism associated with therapy for multi-drug-resistant tuberculosis in Australia. Intern Med J 2019;49:364-372. doi: 10.1111/imj.14085.

Chin AT, Rylance J, Makumbirofa S, Meffert S, Vu T, Clayton J, Mason P, Woodruff P, Metcalfe J. Chronic lung disease in adult recurrent tuberculosis survivors in Zimbabwe: a cohort study. Int J Tuberc Lung Dis 2019;23:203-211. doi: 10.5588/ijtld.18.0313.

Clifford V, Tebruegge M, Zufferey C, Germano S, Forbes B, Cosentino L, Matchett E, McBryde E, Eisen D, Robins-Browne R, Street A, Denholm J, Curtis N. Cytokine biomarkers for the diagnosis of tuberculosis infection and disease in adults in a low prevalence setting. Tuberculosis 2019;114:91-102. doi: 10.1016/ 

Counoupas C, Triccas JA, Britton WJ. Deciphering protective immunity against tuberculosis: implications for vaccine development. Expert Rev Vaccines 2019;18(4):353-364. doi: 10.1080/14760584.2019.1585246

Counoupas C, Triccas JA. The generation of T-cell memory to protect against tuberculosis. Immunol Cell Biol 2019 May 25. doi: 10.1111/imcb.12275.

Detjen AK, Essajee S, Malgorzata G, Marais BJ. Tuberculosis and integrated child health - rediscovering the principles of Alma Ata. Int J Infect Dis 2019. pii: S1201-9712(19)30106-7. doi: 10.1016/j.ijid.2019.02.042

Di Tanna GL, Khaki AR, Theron G, McCarthy K, Cox H, Mupfumi L, Trajman A, Zijenah LS, Mason P et al. Effect of Xpert MTB/RIF on clinical outcomes in routine care settings: individual patient data meta-analysis. Lancet Glob Health 2019;7:e191-e199. doi: 10.1016/S2214-109X(18)30458-3. Erratum in: Lancet Glob Health 2019;7:e419.

Diefenbach-Elstob T, Guernier V, Burgess G, Pelowa D, Dowi R, Gula B, Puri M, Pomat W, McBryde E et al. Molecular Evidence of Drug-Resistant Tuberculosis in the Balimo Region of Papua New Guinea. Trop Med Infect Dis 2019;4. pii: E33. doi: 10.3390/tropicalmed4010033.

Doan TN, Fox GJ, Meehan MT, Scott N, Ragonnet R, Viney K, Trauer JM, McBryde ES. Cost-effectiveness of 3 months of weekly rifapentine and isoniazid compared with other standard treatment regimens for latent tuberculosis infection: a decision analysis study. J Antimicrob Chemother 2019;74(1):218-227. doi: 10.1093/jac/dky403.

Drabarek D, Anh NT, Nhung NV, Hoa NB, Fox GJ, Bernays S. Implementation of Medication Event Reminder Monitors among patients diagnosed with drug susceptible Tuberculosis in rural Viet Nam: A qualitative study. PLoS One 2019;14(7):e0219891. doi: 10.1371/journal.pone.0219891

Fox GJ, Dodd PJ, Marais BJ. Household contact investigation to improve tuberculosis control. Lancet Infect Dis 2019;19(3):235-237. doi: 10.1016/S1473-3099(19)30061-1.

Fox GJ, Nguyen VN, Dinh NS, Nghiem LPH, Le TNA, Nguyen TA, Nguyen BH, Nguyen HD, Tran NB, Nguyen TL, Le TN, Nguyen VH, Phan TL, Nguyen KC, Ho J, Pham DC, Britton WJ, Bestrashniy JRBM, Marks GB. Post-treatment Mortality Among Patients With Tuberculosis: A Prospective Cohort Study of 10 964 Patients in Vietnam. Clin Infect Dis 2019;68(8):1359-1366. doi: 10.1093/cid/ciy665.

Gibson PG; Yang IA; Upham JW; Reynolds PN; Hodge S; James AL; Jenkins C; Peters MJ; Marks GB; Baraket M. Efficacy of azithromycin in severe asthma from the AMAZES randomised trial. ERJ Open Res 2019; 5.

Guernier-Cambert V, Diefenbach-Elstob T, Klotoe B, Burgess G, Pelowa D, Dowi R, Gula B, McBryde E, Refrégier G, Rush C, Sola C, Warner J. Diversity of Mycobacterium tuberculosis in the Middle Fly District of Western Province, Papua New Guinea: microbead-based spoligotyping using DNA from Ziehl-Neelsen-stained microscopy preparations. Scientific Reports 2019: 9: 15549

Graham SM, Sekadde MP. Case detection and diagnosis of tuberculosis in primary-care settings. Paediatr Int Child Health 2019 Apr 8:1-4. doi: 10.1080/20469047.2019.1597487.

Hanigan IC, Rolfe MI, Knibbs LD, Salimi F, Cowie CT, Heyworth J, Marks GB et al. All-cause mortality and long-term exposure to low level air pollution in the '45 and up study' cohort, Sydney, Australia, 2006-2015. Environ Int 2019;126:762-770. doi: 10.1016/j.envint.2019.02.044.

Harries AD, Schwoebel V, Monedero-Recuero I, Aung TK, Chadha S, Graham SM et al. Challenges and opportunities to prevent tuberculosis in people living with HIV in low-income countries. Int J Tuberc Lung Dis 2019;23(2):241-251. doi: 10.5588/ijtld.18.0207.

Hill-Cawthorne G, Negin J, Capon A, Gilbert G, Nind L, Nunn M, Ridgway P, Schipp M, Firman J, Sorrell T, Marais B. Advancing Planetary Health in Australia: focus on emerging infections and antimicrobial resistance. BMJ Global Health 2019;4(2), 1-10.


Honjepari A, Madiowi S, Madjus S, Burkot C, Islam S, Chan G,Majumdar SS, Graham SM. Implementation of screening and management of household contacts of tuberculosis cases in Daru, PNG.  Public Health Action 2019; 9 (Suppl 1): S25-S31


Hortle E, Johnson KE, Johansen MD, Nguyen T, Shavit JA, Britton WJ, Tobin DM, Oehlers SH. Thrombocyte inhibition restores protective immunity to mycobacterial infection in zebrafish. J Infect Dis 2019 Jul 2;220(3):524-534. doi: 10.1093/infdis/jiz110

Huang GKL, Pawape G, Taune M, Hiasihri S, Ustero P, O'Brien DP, du Cros P, Graham S, Wootton R, Majumdar SS. Telemedicine in Resource-Limited Settings to Optimize Care for Multidrug-Resistant Tuberculosis. Front Pub Health 2019.

Huynh J, Marais BJ. Multidrug-resistant Tuberculosis infection and disease in children: a review of new and repurposed drugs. Ther Adv Infect Dis 2019;6:2049936119864737. doi: 10.1177/2049936119864737. Review.

Huynh J, Vosu J, Marais BJ, Britton PN. Multidrug-resistant tuberculous meningitis in a returned traveller. J Paediatr Child Health 2019. doi: 10.1111/jpc.14387.

Jolliffe DA, Ganmaa D, Wejse C, Raqib R, Haq MA, Salahuddin N, Daley PK, Ralph AP, Ziegler TR, Martineau AR. Adjunctive vitamin D in tuberculosis treatment: meta-analysis of individual participant data. Eur Respir J 2019;53(3). pii: 1802003. doi: 10.1183/13993003.02003-2018.

Kendall EA, Sahu S, Pai M, Fox GJ, Varaine F, Cox H, Cegielski JP et al. What will it take to eliminate drug-resistant tuberculosis? Int J Tuberc Lung Dis 2019;23:535-546. doi: 10.5588/ijtld.18.0217.

Keshavjee S, Amanullah F, Cattamanchi A, Chaisson R, Dobos KM, Fox GJ et al. Moving toward Tuberculosis Elimination. Critical Issues for Research in Diagnostics and Therapeutics for Tuberculosis Infection. Am J Respir Crit Care Med 2019;199(5):564-571. doi: 10.1164/rccm.201806-1053PP.

Khatami A, Britton PN, Marais BJ. Management of Children with Tuberculosis. Clin Chest Med 2019;40(4):797-810. doi: 10.1016/j.ccm.2019.08.003. Review.

Kyung HO, Rahevar K, Nishikiori N, Viney K, Choi H, Biermann O, Hee JK. Action towards Universal Health Coverage and social protection for tuberculosis care and prevention: Workshop for End TB Strategy Pillar 2 in the Western Pacific Region 2017. Trop Med Infect Dis 2019;4(1) 3; doi:10.3390/ tropicalmed4010003.

Lavu EK, Johnson K, Banamu J, Pandey S, Carter R, Coulter C, Aia P, Majumdar SS, Marais BJ, Graham SM, Vince J. Drug-resistant Tuberculosis diagnosis since Xpert® MTB/RIF introduction in Papua New Guinea, 2012-2017. Public Health Action 2019;9(Suppl 1):S12-S18. doi: 10.5588/pha.19.0005.

Lestari T, Graham S, van den Boogard C, Triasih R, Poespoprodjo JR, Ubra RR, Kenangalem E, Mahendradhata Y, Anstey NM, Bailie RS, Ralph AP. Bridging the knowledge-practice gap in tuberculosis contact management in a high-burden setting: a mixed-methods protocol for a multicenter health system strengthening study. Implement Sci 2019;14:31. doi: 10.1186/s13012-019-0870-x.

Leung SSY, Carrigy NB, Vehring R, Finlay WH, Morales S, Carter EA, Britton WJ, Kutter E, Chan HK. Jet nebulization of phages with different tail morphologies – structural effects. Int J Pharmaceutics 2019;554:322-326. doi: 10.1016/j.ijpharm.2018.11.026. PMID 30445174.

Lu P; Zhang Y; Lin J; Xia G; Zhang W; Knibbs LD; Morgan GG; Jalaludin B; Marks G; Abramson M. Multi-city study on air pollution and hospital outpatient visits for asthma in China, Environmental Pollution 2019;


Lung T, Marks GB, Nhung NV, Anh NT, Hoa NLP, Anh LTN, Hoa NB, Britton WJ, Bestrashniy J, Jan S, Fox GJ. Household contact investigation for the detection of Tuberculosis in Vietnam: economic evaluation of a cluster-randomised trial. Lancet Glob Health 2019;7(3):e376-e384. doi: 10.1016/S2214-109X(18)30520-5.

Maha A, Majumdar SS, Main S, Phillip W, Witari K, Schulz J, du Cros P. The effects of decentralisation of tuberculosis services in the East New Britain Province, Papua New Guinea. Pub Health Act 2019; 9(Supplement 1):S43-S49.


Mai TQ, Martinez E, Menon R, Van Anh NT, Hien NT, Lan NH, Giang DC, Hang PT, Thuong PH, Van Huan H, Hoang NP, Nhung NV, Hoa NB, Marais BJ, Sintchenko V. Tuberculosis risk factors and Mycobacterium Tuberculosis transmission among HIV-infected patients in Vietnam. Tuberculosis 2019;115:67-75. doi: 10.1016/

Main S, Lestari T, Triasih R, Chan G, Davidson L, Majumdar S, Santoso D, Phung S, Laukkala J, Graham S, du Cros P, Ralph A. Training for Tuberculosis Elimination in Indonesia: Achievements, Reflections, and Potential for Impact. Trop Med Infect Dis 2019; 4(3). pii: E107. doi: 10.3390/tropicalmed4030107.

Marais B. Childhood Tuberculosis. In Samir S. Shah, Alex R. Kemper, Adam J. Ratner (Eds.), Pediatric Infectious Diseases: Essentials for Practice, 2nd Edition, (2019) (pp. 330-341). United States: McGraw-Hill Companies, Inc. Norton, S., Bag, S., Cho, J., Heron, N., Assareh, H., Pavaresh, L., Corbett, S., Marais, B. (2019). Detailed characterisation of the tuberculosis epidemic in Western Sydney: a descriptive epidemiological study. ERJ Open Research, 5(3), 1-10.


Marais BJ, Buddle BM, de Klerk-Lorist LM, Nguipdop-Djomo P, Quinn F, Greenblatt C. BCG vaccination for bovine tuberculosis; conclusions from the Jerusalem One Health workshop. Transbound Emerg Dis 2019;66:1037-1043. doi: 10.1111/tbed.13089.

Marais BJ, Williams S, Li A, Ofrin R, Merianos A, Negin J, Firman J, Davies R, Sorrell T. Improving emergency preparedness and response in the Asia-Pacific. BMJ Glob Health 2019 ;4(1):e001271. doi: 10.1136/bmjgh-2018-001271.

Marais BJ. Newer Drugs for Tuberculosis Prevention and Treatment in Children. Indian J Pediatr 2019. doi: 10.1007/s12098-018-02854-8.

Marks GB, Hansell AL, Johnston FH. The environment is a first order issue for lung health. Int J Tuberc Lung Dis 2019; 23:1239. 1242,


Marks GB, Nguyen NV, Nguyen PTB, Nguyen TA, Nguyen HB, Tran KH, Nguyen SV, Luu KB, Tran DTT, Vo QTN, Le OTT, Nguyen YH, Do VQ, Mason PH, Nguyen VT, Ho J, Sintchenko V, Nguyen LN, Britton WJ, Fox GJ. Community-wide Screening for Tuberculosis in a High-Prevalence Setting. N Engl J Med 2019;381(14):1347-1357. doi: 10.1056/NEJMoa1902129.

Mason PH, Lyttleton C, Marks GB, Fox GJ. The technological imperative in Tuberculosis care and prevention in Vietnam. Glob Public Health 2019:1-14. doi: 10.1080/17441692.2019.1650950

McDonald VM, Fingleton J, Agusti A, Hiles SA, Clark VL, Holland AE, Marks GB, Bardin PP, Beasley R, Pavord ID, Wark PAB, Gibson PG; all the participants in the seminar. Treatable Traits: a new paradigm for 21st century management of chronic airway diseases. Eur Respir J 2019 Mar 7. pii: 1802058. doi: 10.1183/13993003.02058-2018. Review.

Meehan MT, Cocks DG, Müller J, McBryde ES. Global stability properties of a class of renewal epidemic models. J Math Biol 2019. doi: 10.1007/s00285-018-01324-1.

Melsew YA, Cheng AC, McBryde ES, Denholm JT, Tay E, Ragonnet R, Trauer JM. Profiles of tuberculosis disease activation among contacts of patients with tuberculosis. Eur Respir J 2019; DOI: 10.1183/13993003.00353-2019

Melsew YA, Gambhir M, Cheng AC, McBryde ES, Denholm JT, Tay EL, Trauer JM. The role of super-spreading events in Mycobacterium tuberculosis transmission: evidence from contact tracing. BMC Infect Dis 2019 Mar 12;19(1):244. doi: 10.1186/s12879-019-3870-1.

Morris L, Hiasihri S, Chan G, Honjepari A, Tugo O, Taune M, Aia P, Dakulala P, Majumdar SS. The emergency response to multidrug-resistant tuberculosis in Daru, Western Province, Papua New Guinea, 2014–2017. Pub Health Act 2019; 9(Supplement 1):S4-S11.


Nguyen PT, Tran HT, Truong HT, Nguyen VT, Graham SM, Marais BJ. Paediatric use of antibiotics in children with community acquired pneumonia: A survey from Da Nang, Vietnam. J Paediatr Child Health 2019. doi: 10.1111/jpc.14413.

Nguyen PTK, Tran HT, Fitzgerald DA, Tran TS, Graham SM, Marais BJ. Characterisation of children hospitalised with pneumonia in central Vietnam: a prospective study. Eur Respir J 2019;54(1). pii: 1802256. doi: 10.1183/13993003.02256-2018

Norton S, Bag SK, Cho JG, Heron N, Assareh H, Pavaresh L, Corbett S, Marais BJ. Detailed characterisation of the Tuberculosis epidemic in Western Sydney: a descriptive epidemiological study. ERJ Open Res 2019;5(3). pii: 00211-2018. doi: 10.1183/23120541.00211-2018

Oxlade O, Trajman A, Benedetti A, Adjobimey M, Cook VJ, Fisher D, Fox GJ et al. Enhancing the public health impact of latent tuberculosis infection diagnosis and treatment (ACT4): protocol for a cluster randomised trial. BMJ Open 2019: Mar 20;9(3):e025831. doi: 10.1136/bmjopen-2018-025831.

Palagyi A, Marais B, Abimbola F, Topp S, McBryde E, Negin J. Health system preparedness for emerging infectious diseases: A synthesis of the literature. Global Public Health(2019);14(12), 1847-1868.


Pedrazzoli D, Borghi J, Viney K, Houben RMGJ, Lönnroth K. Measuring the economic burden for TB patients in the End TB Strategy and Universal Health Coverage frameworks. Int J Tuberc Lung Dis 2019;23:5-11. doi: 10.5588/ijtld.18.0318.

Petersen E, Rao M, Ippolito G, Chakaya J, Ntoumi F, Moore D, Allen R, Gaskell K, Ohd J, et al, Marais B. "World Tuberculosis Day March 24th 2019 Theme: It's TIME" - International Journal of Infectious Diseases Tuberculosis Theme Series. International Journal of Infectious Diseases (2019): 80, S1-S5.

Phuong NTB, Anh NT, Van Son N, Sintchenko V, Ho J, Fox GJ, Nhung NV, Marks GB. Effect of two alternative methods of pooling sputum prior to testing for Tuberculosis with genexpert MTB/RIF. BMC Infect Dis 2019;19(1):347. doi: 10.1186/s12879-019-3778-9.

Popovic I, Soares Magalhaes RJ, Ge E, Marks GB, Dong GH, Wei X, Knibbs LD. A systematic literature review and critical appraisal of epidemiological studies on outdoor air pollution and tuberculosis outcomes. Environ Res 2019;170:33-45. doi: 10.1016/j.envres.2018.12.011. Review.

Rafiei N, Williams J, Mulley WR, Trauer JM, Jenkin GA, Rogers BA. Mycobacterium tuberculosis: Active disease and latent infection in a renal transplant cohort. Nephrology 2019;24:569-574. doi: 10.1111/nep.13386.

Ragonnet R, Underwood F, Doan T, Rafai E, Trauer J, McBryde E. Strategic Planning for Tuberculosis Control in the Republic of Fiji. Trop Med Infect Dis. 2019 Apr 24;4(2). pii: E71. doi: 10.3390/tropicalmed4020071.

Reid MJA, Arinaminpathy N, Bloom A, Bloom BR, Boehme C… Graham SM et al. Building a tuberculosis-free world: The Lancet Commission on tuberculosis.Lancet. 2019 Mar 30;393(10178):1331-1384. doi: 10.1016/S0140-6736(19)30024-8.

Romanowski K, Baumann B, Basham CA, Ahmad Khan F, Fox GJ, Johnston JC. Long-term all-cause mortality in people treated for tuberculosis: a systematic review and meta-analysis. Lancet Infect Dis 2019;19(10):1129-1137. doi: 10.1016/S1473-3099(19)30309-3

Sabbagh DK, Beasley R, Marks GB. The Immunological Mysteries of Tuberculosis. J Allergy Clin Immunol Prac 2019;7(2):649-650. doi: 10.1016/j.jaip.2018.10.011.

Sanders EJ, Kigoro A, Thiong'o A, Nduati E, Graham SM. Symptom Based Scoring. Clin Infect Dis 2019. doi: 10.1093/cid/ciz059.

Schaaf HS, Marais BJ. The Role of Xpert MTB/RIF Ultra in Diagnosing Pulmonary Tuberculosis in Children. Am J Respir Crit Care Med 2019. doi: 10.1164/rccm.201907-1492ED

Schön T, Matuschek E, Mohamed S, Utukuri M, Heysell S, Alffenaar JW, Shin S, Martinez E, Sintchenko V et al. Standards for MIC testing that apply to the majority of bacterial pathogens should also be enforced for Mycobacterium tuberculosis complex. Clin Microbiol Infect 2019. pii: S1198-743X(19)30041-2. doi: 10.1016/j.cmi.2019.01.019.

Snow KJ, Cruz AT, Seddon JA, Ferrand RA, Chiang SS, Hughes JA et al. Adolescent tuberculosis. Lancet Child Adolesc Health 2019; S2352-4642(19)30337-2

Sodeng K, Yoannes M, Botu A, Semmie M, Shewade HD, Commons R, Graham SM, du Cros P. Challenges in TB diagnosis and treatment: the Kavieng Provincial Hospital experience, Papua New Guinea.  Public Health Action 2019; 9 (Suppl 1): S57-S61

Taune M, Ustero P, Hiashiri S, Huang K, Aia P, Morris L, Main S, Chan G, du Cros P, Majumdar SS. Successful implementation of bedaquiline for multidrug-resistant TB treatment in remote Papua New Guinea. Pub Health Act 2019; 9(Supplement 1):S73-S79


Taylor SL, Leong LEX, Mobegi FM, Choo JM, Wesselingh S ,,, Marks GB et al. Long-Term Azithromycin Reduces Haemophilus influenzae and Increases Antibiotic Resistance in Severe Asthma. Am J Respir Crit Care Med 2019 Mar 15. doi: 10.1164/rccm.201809-1739OC.

Tebruegge M, Ritz N, Donath S, Dutta B, Forbes B, Clifford V, Zufferey C, De Rose R, Robins-Browne RM, Hanekom W, Graham SM et al. Mycobacteria-Specific Mono- and Polyfunctional CD4+ T Cell Profiles in Children With Latent and Active Tuberculosis: A Prospective Proof-of-Concept Study. Front Immunol 2019;10:431. doi: 10.3389/fimmu.2019.00431.

Telnov O, Alvarez V, Graglia E, Molfino L, du Cros P, Rich M. Bedaquiline overdose: A case report. Int J Infect Dis 2019. pii: S1201-9712(19)30164-X. doi: 10.1016/j.ijid.2019.03.035.

Trauer JM, Dodd PJ, Gomes MGM, Gomez GB, Houben RMGJ, McBryde ES et al. The Importance of Heterogeneity to the Epidemiology of Tuberculosis. Clin Infect Dis 2019:18;69(1):159-166. doi: 10.1093/cid/ciy938.

Trauer JM. TB, you’re a long time cured. Eur Respir J 2019;53: pii1900104.

Utiera M, Viney K, Bissell K, Biribo S, Corbett K, Timeon E, Teriboriki B, Tibwe T. Ill-defined Causes of Death in the Republic of Kiribati, 2005 to 2014. Hawaii J Med Public Health 2019;78(3):103-107.

Velizarova S, Gabrovska N, Spasova A, Marais B, Harausz EP, Tiberi S, Migliori GB, Manissero D. Management and outcomes of severe childhood Tuberculosis in the pediatric intensive care setting: can we identify best practices? J Bras Pneumol 2019;45(2):e20190043. doi: 10.1590/1806-3713/e20190043

Viney K, Amaral S, Marques EB, Siroka A, Lopes C, Nery SV. Four of five Tuberculosis patients experience catastrophic costs related to TB diagnosis and care in Timor-Leste. Int J Tuberc Lung Dis 2019;23(11):1191-1197. doi: 10.5588/ijtld.18.0765

Viney K, Islam T, Hoa NB, Morishita F, Lönnroth K. The Financial Burden of Tuberculosis for Patients in the Western-Pacific Region. Trop Med Infect Dis 2019;4(2). pii: E94. doi: 10.3390/tropicalmed4020094. Review.

Viney K, Mills T, Harley D. Tuberculosis and diabetes mellitus: a dose-response relationship between the odds of Tuberculosis and HbA1c. Int J Tuberc Lung Dis 2019;23(10):1055-1059. doi: 10.5588/ijtld.18.0657

Visser SK, Bye PTP, Fox G, ... Britton WJ, Morgan LC. Australian adults with bronchiectasis: The first report from the Australian Bronchiectasis Registry. Respir Med 2019;155:97-103. DOI: 10.1016/ j.rmed.2019.07.016

Williamson DA, Kirk MD, Sintchenko V, Howden BP. The importance of public health genomics to ensure health security for Australia. Med J Aust 2019 Mar 19. doi: 10.5694/mja2.50063.

Visser S, Bye P, Fox G, Burr L, Chang A, King P, Middleton P, Maguire G, Smith D, Thomson R, Britton W et al. Management of Australian Adults with Bronchiectasis in Tertiary Care: Evidence-Based or Access-Driven? Lung 2019;197(6), 803-810.

Williamson DA, Kirk MD, Sintchenko V, Howden BP. The importance of public health genomics to ensure health security for Australia. Med J Aust 2019 Mar 19. doi: 10.5694/mja2.50063. [Epub ahead of print]


2018 Publications

TB-CRE Investigator TB-related publications

Alene KA, Clements ACA, McBryde ES,Jaramillo E, Lönnroth K, Shaweno D, Gulliver A, Viney K. Mental health disorders, social stressors, and health-related quality of life in patients with multidrug-resistant tuberculosis: A systematic review and meta-analysis. J Infect 2018;77(5):357-367. doi: 10.1016/j.jinf.2018.07.007. Epub 2018 Jul 20. Review.

Alene KA, Clements ACA, McBryde ES, Jaramillo E, Lonnroth K, Shaweno D, Viney K. (2018) Sequelae of multidrug-resistant tuberculosis: protocol for a systematic review and meta-analysis. BMJ Open. 8(2):e019593.

Allix-Beguec C, Arandjelovic I, Bi L, Beckert P, Bonnet M, Bradley P, Sintchenko V et al for The CRyPTIC Consortium and the 100,000 Genomes Project. Prediction of susceptibility to first-line tuberculosis drugs by DNA sequencing. New Eng J Med 2018;379(15):1403-1415

Ashhurst AS, Parumasivam T, John JGY, Lin LC, Flórido M, West NP, Chan H-K, Britton WJ.(2018).  PLGA particulate subunit tuberculosis vaccines promote humoral responses but not protective immunity against Mycobacterium tuberculosis. PLoS ONE 13(3):e0194620.

Aye S, Majumdar SS, Oo MM, Tripathy JP, Satyanarayana S, Kyaw NTT, Kyaw KWY, Oo NL, Thein S, Thu MK, Soe KT, Aung ST. Evaluation of a tuberculosis active case finding project in peri-urban areas, Myanmar: 2014-2016. Int J Infect Dis. 2018 May;70:93-100. doi: 10.1016/j.ijid.2018.02.012.

Bachmann NL, Rockett RJ, Timms VJ, Sintchenko V.Advances in Clinical Sample Preparation for Identification and Characterization of Bacterial Pathogens Using Metagenomics. Front Public Health 2018 Dec 12;6:363. doi: 10.3389/fpubh.2018.00363. eCollection 2018. Review.

Bainomugisa A, Duarte T, Lavu E, Pandey S, Coulter C, Marais BJ, Coin L. A complete high-quality MinION nanopore assembly of an extensively drug-resistant Mycobacterium tuberculosis Beijing lineage strain identifies novel variation in repetitive PE/PPE gene regions. Microbial Genomics 2018;4(7). doi: 10.1099/mgen.0.000188.

Bainomugisa A, Lavu E, Hiashiri S, Majumdar S, Honjepari A, Moke R, Dakulala P, Hill-Cawthorne GA, Pandey S, Marais BJ, Coulter C, Coin L. (2018) Multi-clonal evolution of multi-drug-resistant/extensively drug-resistant Mycobacterium tuberculosis in a high-prevalence setting of Papua New Guinea for over three decades. Microb Genom. doi: 10.1099/mgen.0.000147. [Epub ahead of print]

Baird T, Donnan E, Coulter C,Simpson G, Konstantinos A, Eather G. Multidrug-resistant tuberculosis in Queensland, Australia: an ongoing cross-border challenge. Int J Tuberc Lung Dis. 2018 Feb 1;22(2):206-211. doi: 10.5588/ijtld.17.0180.

Barry SE, Ellis M Yang YR, Guan G, Wang X,Britton WJ, Saunders BM. (2018) Identification of a plasma microRNA profile in pulmonary tuberculosis patients that is modulated by anti-microbial therapy. Journal of Infection (accepted 19/3/2018).

Bastard M, Sanchez-Padilla E, du Cros P, Khamraev AK, Parpieva N, Tillyashaykov M et al. Outcomes of HIV-infected versus HIV-non-infected patients treated for drug-resistance tuberculosis: Multicenter cohort study. PLoS One. 2018 Mar 8;13(3):e0193491. doi: 10.1371/journal.pone.0193491. eCollection 2018.

Bastian I, Coulter C; National Tuberculosis Advisory Committee (NTAC). Position statement on interferon-γ release assays for the detection of latent tuberculosis infection. Commun Dis Intell Q Rep. 2017 Dec 1;41(4):E322-E336. Review.

Birungi FM, Graham S, Uwimana J, van Wyk B. (2018) Assessment of the isoniazid preventive therapy uptake and associated characteristics: a cross-sectional study. Tuberc Res Treat.

Byrne AL, Marais BJ, Mitnick CD, Garden FL, Lecca L, Contreras C, Yauri Y, Garcia F, Marks GB. (2018) Feasibility and yield of screening for non-communicable diseases among treated tuberculosis patients in Peru. Int J Tuberc Lung Dis.22(1):86-92.

Byrne AL, Fox GJ, Marais BJ.(2018) Better than a pound of cure: preventing the development of multidrug-resistant tuberculosis. Future Microbiol. doi: 10.2217/fmb-2017-0236. [Epub ahead of print]

Chang RY, Wong J, Mathai A, Morales S, Kutter E, Britton WJ, Li J, Chan H-K (2018). Production of highly stable spray dried phage formulations for treatment of Pseudomonas aeruginosa lung infection. European Journal of Pharmaceutics and Biopharmaceutics, 121:1-13.

Chang RY, Chen K, Wang J, Wallin M, Britton WJ,Morales S, Kutter E, Li J, Chan H-K (2018) Anti-Pseudomonal activity of phage PEV20 in a dry powder formulation in a murine lung infection model–A proof-of-principle study. Antimicrobial Agents and Chemotherapy Jan 25;62 (2). 

Cheah ALY, Cheng AC, Spelman D, Nation RL, Kong DCM, McBryde ES. Mathematical modelling of vancomycin-resistant enterococci transmission during passive surveillance and active surveillance with contact isolation highlights the need to identify and address the source of acquisition. BMC Infect Dis 2018;18(1):511. doi: 10.1186/s12879-018-3388-y.

Cheung YM, Van K, Lan L, Barmanray R, Qian SY, Shi WY, Wong J, Hamblin PS, Colman PG, Topliss DJ, Denholm JT, Grossmann M. Hypothyroidism associated with therapy for multi-drug resistant tuberculosis in Australia. Intern Med J. 2018 Aug 27. doi: 10.1111/imj.14085. [Epub ahead of print]

Clifford S, Mazaheri M, Salimi F, Ezz WN, Yeganeh B, Low-Choy S, Walker K, Mengersen K, Marks GB, Morawska L. (2018) Effects of exposure to ambient ultrafine particles on respiratory health and systemic inflammation in children. Environ Int. 114:167-180.


Counoupas C, Pinto, R, Gayathri N, Britton WJ, Triccas JA. (2018) Protective efficacy of recombinant BCG over-expressing protective, stage-specific antigens of Mycobacterium tuberculosis. Vaccine. 36(19):2619-2629. doi: 10.1016/j.vaccine.2018.03.066.

Dale KD, Trauer JM, Dodd PJ, Houben RMGJ, Denholm JT. Estimating the prevalence of latent tuberculosis in a low-incidence setting: Australia. Eur Respir J. 2018 Dec 20;52(6). pii: 1801218. doi: 10.1183/13993003.01218-2018.

Denholm JT, Silva DS, Burhan E, Chaisson RE. Tuberculosis Elimination in the Asia-Pacific Region and the WHO Ethics Guidance. Trop Med Infect Dis. 2018 Oct 31;3(4). pii: E115. doi: 10.3390/tropicalmed3040115.

Detjen AK, McKenna L, Graham SM, Marais BJ, Amanullah F; WHO/STOP TB Partnership Child and Adolescent TB Working Group. (2018) The upcoming UN general assembly resolution on tuberculosis must also benefit children. Lancet Glob Health. 6(5):e485-e486. doi: 10.1016/S2214-109X(18)30108-6.

Doan TN, Cao P, Emeto TI, McCaw JM, McBryde ES. Predicting the Outcomes of New Short-Course Regimens for Multidrug-Resistant Tuberculosis Using Intrahost and Pharmacokinetic-Pharmacodynamic Modeling. Antimicrob Agents Chemother 2018 Nov 26;62(12). pii: e01487-18. doi: 10.1128/AAC.01487-18. Print 2018 Dec.

Dobler CC, Bosnic-Anticevich S, Armour CL. Physicians' perspectives on communication and decision making in clinical encounters for treatment of latent tuberculosis infection. ERJ Open Res. 2018 Mar 23;4(1). pii: 00146-2017. doi: 10.1183/23120541.00146-2017

Dobler CC, Fox GJ,Douglas P, Viney KA, Ahmad Khan F, Temesgen Z, Marais BJ. (2018) Screening for tuberculosis in migrants and visitors from high incidence settings: present and future perspectives. Eur Respir J. pii: 1800591. doi: 10.1183/13993003.00591-2018. [Epub ahead of print]

Edwards J, Wilmott JS, Madore J, Gide TN, Quek C, Hewavisenti, R, Hersey P, Weninger W, Britton WJ,Saw RPM, Thompson JF, Menzies AM, Long GV, Scolyer RA, Palendira U. (2018).  CD103+ tumor-resident CD8+ T cells are associated with improved survival in immunotherapy naive melanoma patients and expand significantly during anti-PD1 treatment. Clinical Cancer Research (accepted 23/2/2108).

Elliot C, Marais B,Williams P, Joshua P, Towle S, Hart G, Zwi K. (2018) Tuberculin skin test versus interferon-gamma release assay in refugee children: A retrospective cohort study. J Paediatr Child Health. doi: 10.1111/jpc.13865. [Epub ahead of print]

Flórido M, Muflihah H, Lin LCW, Xia Y, Sierro F, Palendira M, Feng CG, Bertolino P, Stambas J, Triccas JA, Britton WJ.Pulmonary immunization with a recombinant Influenza A virus vaccine induces lung-resident CD4+ memory T cells that are associated with protection against tuberculosis. Mucosal Immunol 2018;11:1743–1752. PMID: 30115996

Fox GJ, Nguyen VN, Dinh NS, Nghiem LPH, Le TNA, Nguyen TA, Nguyen BH, Nguyen HD, Tran NB, Nguyen TL, Le TN, Nguyen VH, Pham TL, Nguyen KC Ho J, Pham DC, Britton WJ, Bestrashniy J, Marks GB.Post-treatment mortality among patients with tuberculosis: a prospective cohort study of 10,964 patients in Vietnam. Clin Infect Dis 2018. doi: 10.1093/cid/ciy665. [Epub ahead of print]. PMID 30202910.

Fox GJ, Nhung NV, Hoa NLP, Ngoc Anh LT, Thu Anh N, Hoa NB, Buu TN, Loi NT, Nhung LT, Hung NV, Lieu PT, Cuong NK, Ho J, Cuong P, Britton WJ, Bestrashniy J, Marks GB.Recurrence of Tuberculosis Among Patients Following Treatment Completion in Eight Provinces of Vietnam: A Nested Case-Control Study. Int J Infect Dis 2018;74:31-37. PMID 29944930.

Fox GJ,Nhung NV, Sy DN, Hoa NLP, Anh LTN, Anh NT, Hoa NB, Dung NH, Buu TN, Loi NT, Nhung LT, Hung NV, Lieu PT, Cuong NK, Cuong PD, Bestrashniy J, Britton WJ, Marks GB. (2018) Household-Contact Investigation for Detection of Tuberculosis in Vietnam. N Engl J Med. 378(3):221-229.

Francis JR, Manchikanti P, Blyth CC, Denholm J,Lowbridge C, Coulter C, Donnan E, Stapledon R, Krause VL, Waring J. (2018) Multidrug-resistant tuberculosis in Australia, 1998-2012. Int J Tuberc Lung Dis. 22(3):294-299.

Garden FL, Toelle BG, Mihrshahi S, Webb KL, Almqvist C, Tovey ER, Brew BK, Ayer JG, Skilton MR, Jones G, Ferreira MAR, Cowie C, Weber C, Britton WJ,Celermajer DS, Leeder SL, Peat JK, Marks GB.Cohort Profile: Childhood Asthma Prevention Study (CAPS). Int J Epidemiol 2018;1–12 doi: 10.1093/ije/dyy078. [May 25 Epub ahead of print] PMID:29800224

Gibson J, Coucher J, Coulter C, Eather G. Pleuropulmonary tuberculosis with spinal lesions due to metastatic malignancy differentiated definitively on imaging. BMJ Case Rep. 2018 Dec 22;11(1). pii: e226160. doi: 10.1136/bcr-2018-226160.

Guernier V, Diefenbach-Elstob T, Pelowa D, Pollard S, Burgess G, McBryde ES, Warner J. Molecular diagnosis of suspected tuberculosis from archived smear slides from the Balimo region, Papua New Guinea. Int J Infect Dis 2018;67:75-81.


Hansell AL, Bakolis I, Cowie CT, Belousova EG, Ng K, Britton WJ, Leeder S, Tovey E, Webb K, Toelle BG, Marks GB. Childhood fish oil supplementation modifies associations between road density and allergic sensitisation. Environ Health 2018 17:27. doi: 10.1186/s12940-018-0370-5.

Hawkins PME, Giltrap AM, Nagalingam G, Britton WJ, Payne RJ. Total Synthesis of Ecumicin. Org Lett 2018;20:1019-1022.

Horwood PF, McBryde ES,Peniyamina D, Ritchie SA. The Indo-Papuan conduit: a biosecurity challenge for Northern Australia. Aust N Z J Public Health. 2018;42:434-436. doi: 10.1111/1753-6405.12808. Epub 2018 Aug 8. No abstract available.

Hulme KM, Isaacs D2, Marais BJ,Robinson PD. Spontaneous Pneumothorax in a Young Child With Pulmonary Tuberculosis. Pediatr Infect Dis J 2018; doi: 10.1097/INF.0000000000002018. [Epub ahead of print]

Johansen MD, Kasparian JA, Hortle E, Britton WJ,Purdie AC, Oehlers SH. Mycobacterium marinum infection drives foam cell differentiation in zebrafish infection models. Dev Comp Immunol 2018;88:169-172. doi: 10.1016/j.dci.2018.07.022. [Epub ahead of print] 

Johansen, MD, Hortle E, Kasparian JA, Romero A, Novoa B, Figueras A, Britton WJ, de Silva K, Purdie AC, Oehlers SH. Analysis of mycobacterial infection-induced changes to host lipid metabolism in a zebrafish infection model reveals a conserved role for LDLR in infection susceptibility. Fish and Shellfish Immunol 2018;83:238-242. DOI: 10.1016/j.fsi.2018.09.037. 

Karmakar M, Globan M, Fyfe JAM, Stinear TP, Johnson PDR, Holmes NE, Denholm JT, Ascher DB. Analysis of a Novel pncA Mutation for Susceptibility to Pyrazinamide Therapy. Am J Respir Crit Care Med 2018;198:541-544. doi: 10.1164/rccm.201712-2572LE. 

Kaushik N, Lowbridge C, Scandurra G, Dobler CC. Post-migration follow-up programme for migrants at increased risk of developing tuberculosis: a cohort study. ERJ Open Res 2018;4. pii: 00008-2018. doi: 10.1183/23120541.00008-2018.

Kinner SA,Snow K, Wirtz AL, Altice FL, Beyrer C, Dolan K. Age-Specific Global Prevalence of Hepatitis B, Hepatitis C, HIV, and Tuberculosis Among Incarcerated People: A Systematic Review. J Adolesc Health 2018;62:S18-S26. doi: 10.1016/j.jadohealth.2017.09.030. Review.

Kuhlin J, Smith C, Khaemraev A, Tigay Z, Parpieva N, Tillyashaykhov M, Achar J, Hajek J, Greig J, du Cros P, Moore D. Impact of pyrazinamide resistance on multidrug-resistant tuberculosis in Karakalpakstan, Uzbekistan. Int J Tuberc Lung Dis 2018;22:544-550. doi: 10.5588/ijtld.17.0483.

Leung SSY, Morales S, Britton W, Kutter E, Chan H-K. Microfluidic-assisted bacteriophage encapsulation into liposomes. Int J Pharmaceut 2018;545(1-2):176-182. (ePub 2/5/20018) PMID 29729404.

Leung SSY, Parumasivam T, Nguyen A, Gengenbach T, Carter EA, Carrigy NB, Wang H, Vehring R, Finlay WH, Morales S, Britton WJ,Kutter E, Chan HK. Effect of Storage Temperature on the Stability of Spray Dried Bacteriophage Powders. Eur J Pharm Biopharm 2018;pii: S0939-6411(17)31249-3.

Leung SSY, Morales S, Britton W, Kutter E, Chan HK. Microfluidic-assisted bacteriophage encapsulation into liposomes. Int J Pharm 2018;545(1-2):176-182. doi: 10.1016/j.ijpharm.2018.04.063.

Lin Y, Chang RYK, Britton WJ, Morales S, Kutter E, Chan HK. Synergy of nebulized phage PEV20 and ciprofloxacin combination against Pseudomonas aeruginosa. Int J Pharmaceutics 2018;551(1-2):158-165. PMID: 30223075.

Marais BJ,Buddle BM, de Klerk-Lorist L, Nguipdop-Djomo P, Quinn F, Greenblatt C. Developments in BCG vaccination for bovine tuberculosis; conclusions from a One Health Workshop. Transbound Emerg Dis 2018;1-7. Epub ahead of print. doi: 10.1111/tbed.13089.

Marais BJ. Symptom-based screening of children with household tuberculosis contact. Lancet Respir Med 2018;6(4):235-237. doi: 10.1016/S2213-2600(17)30496-4.

Marks GB, Nhung NV, Nguyen TA, Hoa NB, Khoa TH, Son NV, Phuong NTB, Tin DM, Ho J, Fox GJ. Prevalence of latent tuberculous infection among adults in the general population of Ca Mau, Viet Nam. Int J Tuberc Lung Dis 2018;22:246-251.

Martinez E, Hennessy D, Jelfs P, Crighton T, Chen SC, Sintchenko V. Mutations associated with in vitro resistance to bedaquiline in Mycobacterium tuberculosis isolates in Australia. Tuberculosis 2018;111:31-34.

Meehan MT, Cocks DG, Trauer JM, McBryde ES. Coupled, multi-strain epidemic models of mutating pathogens. Math Biosci 2018;296:82-92.

Melsew YA, Doan TN, Gambhir M, Cheng AC, McBryde E, Trauer JM. Risk factors for infectiousness of patients with tuberculosis: a systematic review and meta-analysis. Epidemiol Infect 2018;146:345-353.

Muflihah H, Flórido M, Lin LCW, Xia Y, Triccas JA, Stambas J, Britton WJ. Sequential pulmonary immunization with heterologous recombinant Influenza A virus tuberculosis vaccines protects against murine M. tuberculosis infection. Vaccine 2018;36:2462-2470.


Murray H, Tay EL, Dinh S, Matthews H, Street A, Denholm JT. The Use of Fluoroquinolones for Tuberculosis in Victoria between 2011 and 2016. Tuberc Res Treat 2018;6860479. doi: 10.1155/2018/6860479. eCollection 2018.

Nguyen VAT, Nguyen HV, Dinh TV, Du HH, Do CN, Marks GB,Nguyen NV. Evaluation of Loopamp™MTBC detection kit for diagnosis of pulmonary tuberculosis at a peripheral laboratory in a high burden setting. Diagn Microbiol Infect Dis 2018;90(3):190-195.

Nguyen P, Nguyen S, Nguyen T, Marais B. TB presenting as recurrent pneumonia in a HIV-infected infant in central Viet Nam. Reports 2018;1, 12;

Nguyen PTK, Thai TTB, Huynh J, Marais BJ.Infant with Xpert® confirmed tuberculous meningitis in central Vietnam. J Clin Med 2018;7,397; doi:10.3390/jcm7110397.

Nguyen PTK, Tran HT, Thai TTT, Foster K, Roberts CL, Marais BJ. (2018) Factors associated with breastfeeding intent among mothers of newborn babies in Da Nang, Viet Nam. Int Breastfeed J. 13:2. doi: 10.1186/s13006-017-0144-7.

Nguyen N, Wilson DW, Nagalingam G, Triccas JA, Schneider EK, Li J, Velkov T, Baell J. (2018) Broad activity of diphenyleneiodonium analogues against Mycobacterium tuberculosis, malaria parasites and bacterial pathogens. Eur J Med Chem. 148:507-518.

Pandey S, Lavu E, Congdon J, Moke R, Bainomugisa A, Coulter C. Characterization of pncA mutations in multi-drug and pyrazinamide resistant Mycobacterium tuberculosis isolates cultured from Queensland migrants and Papua New Guinea residents. Tuberculosis (Edinb). 2018 Jul;111:109-113. doi: 10.1016/ Epub 2018 Jun 8.

Parvaresh L, Bag SK, Cho J, Heron N, Assareh H, Norton S, Corbett S, Marais BJ. Monitoring Tuberculosis Contact Tracing Outcomes in Western Sydney, Australia. BMJ Open Resp Research 2018; 5(1):e000341. doi: 10.1136/bmjresp-2018-000341

Parvaresh L, Crighton T, Martinez E, Bustamante A, Chen S, Sintchenko V. Recurrence of tuberculosis in a low-incidence setting: a retrospective cross-sectional study augmented by whole genome sequencing. BMC Infect Dis 2018;18(1):265. doi: 10.1186/s12879-018-3164-z.

Shaweno D, Karmakar M, Alene KA, Ragonnet R, Clements AC, Trauer JM, Denholm JT, McBryde ES. Methods used in the spatial analysis of tuberculosis epidemiology: a systematic review. BMC Med 2018;16(1):193. doi: 10.1186/s12916-018-1178-4.

Shaweno D, Trauer JM, Denholm JT, McBryde ES.The role of geospatial hotspots in the spatial spread of tuberculosis in rural Ethiopia: a mathematical model. R Soc Open Sci 2018;19;5:180887. doi: 10.1098/rsos.180887. eCollection 2018 Sep.

Snow KJ, Sismanidis C, Denholm J, Sawyer SM, Graham SM. The incidence of tuberculosis among adolescents and young adults: a global estimate. Eur Respir J 2018;51(2). pii: 1702352. Antitubercular Bis-Substituted Cyclam Derivatives: Structure-Activity Relationships and in Vivo Studies. J Med Chem. 61(8):3595-3608. doi: 10.1021/acs.jmedchem.7b01569.

Snow KJ, Nelson LJ, Sismanidis C, Sawyer SM, Graham SM. Incidence and prevalence of bacteriologically confirmed pulmonary tuberculosis among adolescents and young adults: a systematic review. Epidemiol Infect 2018 [Epub ahead of print].

Snow K, Yadav R, Denholm J,Sawyer S, Graham S. Tuberculosis among children, adolescents and young adults in the Philippines: a surveillance report. Western Pac Surveill Response J 2018;9:16-20. doi: 10.5365/wpsar.2017.8.4.011. eCollection 2018 Oct-Dec.

Spain M, Wong JK, Nagalingam G, Batten JM, Hortle E, Oehlers SH, Jiang XF, Murage HE, Orford JT, Crisologo P, Triccas JA, Rutledge PJ, Todd MH. (2018) 

Strong EJ, West NP. Use of Soluble Extracellular Regions of MmpL (SERoM) as Vaccines for Tuberculosis. Scientific Reports 2018;8, Article number 5604. doi:10.1038/s41598-018-23893-3


Sun HK, Pang A, Farr DC, Mosaiab T, Britton WJ,Anoopkumar-Dukie S, Grice ID, Kiefel MJ, West N, Grant GD, Houston TA. Thioamide Derivative of the Potent Antitubercular Decanesulfonylacetamide is Less Active Against M. tuberculosis but a More Potent Anti-staphylococcal Agent. Aust J Chem 2018;71(9): 716-719. (epub 19/9/2018).

Tramontana AR, Leslie DE, Nolan A, Globan M, Fyfe JM, Denholm JT, Guy SD. Pulmonary extensively drug-resistant tuberculosis in Melbourne: local control of a global health challenge. Med J Aust. 2018 Jun 4;208(10):428-429. No abstract available.

Trauer JM, Dodd PJ, Gomes MGM, Gomez GB, Houben RM, McBryde ES,Melsew YA, Menzies NA, Arinaminpathy N, Shrestha S, Dowdy DW. The Importance of Heterogeneity to the Epidemiology of Tuberculosis. Clin Infect Dis 2018. doi: 10.1093/cid/ciy938. [Epub ahead of print]

Trinh QM, Martinez E, Menon R, Nguyen TVA, Nguyen TH, Marais BJ, Sintchenko V. Mycobacterium tuberculosis drug resistance and transmission among HIV-infected patients in Ho Chi Minh City, Vietnam. Am J Trop Med Hyg 2018;99: 1397-1406.

Zhang G, deWeerd NA, Stifter SA, Liu L, Zhou B, Wang W, Zhou Y, Ying B, Hu X, Matthews AY, Ellis M, Triccas JA, Hertzog PJ, Britton WJ, Chen X, Feng CG. A proline deletion in IFNAR1 impairs IFN-signaling and underlies increased resistance to tuberculosis in humans. Nat Commun 2018;9(1):85. PMID: 29311663.

2017 Publications

TB-CRE Investigator TB-related publications

Al Yazidi, L.S.,  Marais, B.J., Briony, Hazelton, B., Outhred, A., Kesson, A. (2017). Nontuberculous mycobacteria in children – a focus on bloodstream infections. Ped Infect Dis J: 36: 374-8

Alene, K.A., Viney, K., McBryde, E., Clements, A. (2017).  Spatial patterns of multidrug resistant tuberculosis and its relationship to socio-economic, demographic and household factors in northwest Ethiopia. PLoS One. 2017; 12(2): e0171800. 

Alene, K.A., Viney, K., McBryde,E.S., Tsegaye, A.T. (2017).  Clements AC. Treatment outcomes in patients with multidrug‐resistant tuberculosis in north‐west Ethiopia. Tropical Medicine & International Health.

Abimbola S, Topp S, Palagyi A, Marais B,Negin J. (2017) Global health security: where is the data to inform health system strengthening? BMJ Glob Health.2(3):e000481.

Barry, S.E., Ellis, M. Yang, Y.R., Guan, G., Wang, X., Britton, W.J., Saunders, B.M. (2017). Identification of a plasma microRNA profile in pulmonary tuberculosis patients that is modulated by anti-microbial therapy. (submitted).

Bates, M., Hassan, R., Marais, B.,Ntoumi, F., Yeboah-Manu, D. (2017). Challenging dogma and stagnation in TB research. Int. J. Mycobacteriol: 5: 373

Borisov, S., Dhedai, K., Enwerem, M… Denholm, J.T, …Migliori, G.B. (2017). Effectiveness and safety of bedaquiline-containing regimens in the treatment of multidrug and extensively drug-resistant tuberculosis: a multicentre study. Euro Resp J. 49(5). pii: 1700387.

Byrne AL, Marais BJ,Mitnick CD, Garden FL, Lecca L, Contreras C, Yauri Y, Garcia F, Marks GB. (2017) Chronic airflow obstruction after successful treatment of multidrug-resistant tuberculosis. ERJ Open Res. 3(3).

Byrne AL, Fox G, Marais BJ. (2017) Better than a pound of cure: steps to prevent multidrug resistant tuberculosis. Fut Microbiol. 13:5.

Carrigy NB, Chang RY, Leung SSY, Harrison M, Petrova Z, Pope WH, Hatfull GF, Britton WJ, Chan HK, Sauvageau D, Finlay WH, Vehring R. (2017) Anti-Tuberculosis Bacteriophage D29 Delivery with a Vibrating Mesh Nebulizer, Jet Nebulizer, and Soft Mist Inhaler. Pharm Res. 34(10):2084-2096.

Clifford V, Tebruegge M, Zufferey C, Germano S, Forbes B, Cosentino L, McBryde E, Eisen D, Robins-Browne R, Street A, Denholm J, Curtis N. (2017) Mycobacteria-specific cytokine responses as correlates of treatment response in active and latent tuberculosis. J Infect. 75(2):132-145.

Coffman J, Chanda-Kapata P, Marais BJ, Kapata N, Zumla A, Negin J. (2017) Tuberculosis among older adults in Zambia: burden and characteristics among a neglected group. BMC Public Health.17(1):804.

Counoupas C, Pinto R, Nagalingam G, Britton WJ,Petrovsky N, Triccas JA. (2017) Delta inulin-based adjuvants promote the generation of polyfunctional CD4+ T cell responses and protect mice against Mycobacterium tuberculosis infection. Sci Rep. 7(1):8582.

Counoupas, C., Pinto, R., Nagalingam, G., Britton ,W.J.,Petrovsky, N., Triccas,J.A. Coussens, A.K., Mason, P.H., Oni, T. (2017) Socio-political prescriptions for LTBI are required to prevent re-activation of TB, Int J Infect Dis. 58:115-116

Counoupas C, Pinto R, Nagalingam G, Britton WJ, Petrovsky N,Triccas JA. (2017) Delta inulin-based adjuvants promote the generation of polyfunctional CD4+ T cell responses and protection against Mycobacterium tuberculosis infection. Sci Rep.7(1):8582.

Dale, K.D., Globan, M., Tay, E., Trevan, P.G., Denholm, J.T.(2017).  Recurrence of tuberculosis in a low-incidence setting without Directly Observed Treatment (DOT): Victoria, 2002-2014. Int J TB Lung Dis, January 2017.

Dale KD, Tay EL, Trauer JM, Trevan PG, Denholm JT.(2017) Comparing tuberculosis management under public and private healthcare providers: Victoria, Australia, 2002-2015. BMC Infect Dis. 17(1):324.

Dale K, Tay E, Trauer JM,Trevan P, Denholm J.(2017) Gender differences in tuberculosis diagnosis, treatment and outcomes in Victoria, Australia, 2002-2015. Int J Tuberc Lung Dis. 21(12):1264-1271.

Degeling, C., Denholm, J.T., Mason, P.,Kerridge, I.H,, Dawson, A. (2017).  Eliminating latent tuberculosis in low burden settings: are the principal beneficiaries to be disadvantaged groups or the broader population? J Med Ethics. 43(9):632-636.

Denholm JT.(2017) Strategic partnerships towards tuberculosis elimination. Int J Tuberc Lung Dis. 21(10):1072.

Denholm JT, Bissell K, Viney K, Durand AM, Cash HL, Roseveare C, Merilles OE Jr, Harries AD, Biribo S. (2017) Research ethics committees in the Pacific Islands: gaps and opportunities for health sector strengthening. Public Health Action. 7(1):6-9.

Denholm, J.T., McBryde, E.S., Eisen, D.E., Street, A.C., Matchett, E., Chen, C., Shultz, T., Biggs, B.A., Leder, K. SIRCLE – a randomised controlled cost comparison of self-administered. Short-course Isoniazid and Rifapentine for Cost-effective Latent tuberculosis Eradication. Intern Med J. 47(12):1433-1436

Feng, C.G., JCI Zhang, G., deWeerd, N.A, Stifter, S.A., Liu, L., Zhou, B., Wang, W., Zhou, Y., Matthews, A., Ellis, M., Triccas, J.A., Hertzog, P.J., Britton, W.J., Chen, X., Feng, C.G. (2017) Muted type-I interferon signaling underlies enhanced resistance to human tuberculosis, PLOS Pathogens (under revision)

Fox, G.J., Dobler, C., Marais, B.J., Denholm, J. (2017).  Preventive therapy for latent tuberculosis infection – the promise and challenges. Int J Infect Dis; 56: 68-76

Fox, G.J., Schaaf, H.S., Mandalakas, A., Chiappini, E., Zumla, A., Marais, B.J. (2017).  Preventing the spread of multidrug-resistant tuberculosis and protecting contacts of infectious cases: a systematic review. Clin Microbiol Infect; 23:147-153

Fox GJ, Anh NT, Nhung NV, Loi NT, Hoa NB, Ngoc Anh LT, Cuong NK, Buu TN, Marks GB,Menzies D. (2017) Latent tuberculous infection in household contacts of multidrug-resistant and newly diagnosed tuberculosis. Int J Tuberc Lung Dis. 21(3):297-302.

Graham SM.(2017) The management of infection with Mycobacterium tuberculosis in young children post-2015: an opportunity to close the policy-practice gap. Expert Rev Respir Med. 11(1):41-49.

Hansell, A.L., Bakolis, I., Cowie, C.T., Belousova, E.G., Ng, K., Britton, W.J., Leeder, S., Tovey, E., Webb, K., Toelle, B.G., Marks, G.B. (2017). Childhood fish oil supplementation modifies  associations between road density and allergic sensitisation. Clin Exp Allergy 

Harausz, E., Garcia-Prats, A., Seddon, J,. Schaaf, H.S., Achar, J., Becerra, M., Bernheimer, J., Cruz, A., D’Ambrosio, L., Detjen, A., Graham, S., Marais, B.J., Jonckheree, S., Lessem, E., Migliori, G.B, McKenna, L., Skrahina, A., Duran, L.T,, Wilson, P., Furin, J. (2017). New/Repurposed Drugs for Pediatric Multidrug-Resistant Tuberculosis: Practice-Based Recommendations. Am J Resp Crit Care Med.

Harausz, E.P., Garcia-Prats, A.J., Seddon, J.A,. Schaaf, H.S., Hesseling, A.C., Achar, J,. Bernheimer, J., Cruz, A., D'Ambrosio, L., Detjen, A., Graham, S.M., Hughes, J., Jonckheere, S., Marais, B.J., Battista, Migliori. G., McKenna, L., Skrahina, A., Tadolini, M., Wilson, P., Furin, J. (2017). Sentinel Project on Pediatric Drug-Resistant Tuberculosis. Am J Respir Crit Care Med.

Hare, N.J., Lee, L.Y., Loke, I,. Britton, W.J,. Saunders, B.M., Thaysen-Andersen, M. (2017) Mycobacterium tuberculosis Infection Manipulates the Glycosylation Machinery and the N-Glycoproteome of Human Macrophages and their Microparticles. J Proteome Research 16(1):247-263. 

Hill-Cawthorne G, Marais BJ. Zika virus – brief overview. Springer Nature 2016. March 29.… @SpringerNature

Hill-Cawthorne GA, Capon AG, Sorrell TC, Marais BJ. (2017) A planetary health approach to emerging infections in Australia. Lancet. 389(10076):1293.

Ho J, Jelfs P, Nguyen P, Sintchenko V, Fox G, Marks GB. Pooling sputum samples to improve the feasibility of Xpert MTB/RIF in systematic screening for tuberculosis. Int J Tuberc Lung Dis. 21(5):503-508.

Jenkins HE, Yuen CM, Rodriguez CA, Nathavitharana RR, McLaughlin MM, Donald PR, Khatami A, Outhred AC, Maldigri PI, Isaacs D, Marais BJ, Kesson AM. Nosocomial transmission from a child with sputum smear-negative pulmonary tuberculosis. Ped Infect Dis J 2017; E-pub ahead of print

Jenkins HE, Yuen CM, Rodriguez CA, Nathavitharana RR, McLaughlin MM, Donald PR, Marais BJ, Becerra MC (2017) Mortality among children diagnosed with tuberculosis: Systematic review and meta-analysis. Lancet Infect Dis. 17: 285-95

Kastien-Hilka T, Rosenkranz B, Sinanovic E, Bennett B, Schwenkglenks M. (2017) Health-related quality of life in South African patients with pulmonary tuberculosis. PLoS One. 12(4):e0174605.

Kastien-Hilka T, Rosenkranz B, Schwenkglenks M, Bennett BM, Sinanovic E. (2017) Association between Health-Related Quality of Life and Medication Adherence in Pulmonary Tuberculosis in South Africa. Front Pharmacol.8:919.

Kaufmann SHE, Dockrell HM, Drager N, Ho M, McShane H, Neyrolles O, Ottenhoff T, Patel B, Roordink D, Britton W, Triccas J, Counoupas C, et al (2017). TBVAC2020: Advancing tuberculosis vaccines from discovery to clinical development. Frontiers in Immunology.  Oct 4, 8:1203. 

Khatami A, Marais B. (2017) The Epidemiology of Tuberculosis in Children. J Ped Infect Dis. 01:1-88

LaCourse SM, Deya RW, Graham SM, Masese LN, Jaoko W, Mandaliya KN, Overbaugh J, McClelland RS. (2017) Evaluation of the Isoniazid Preventive Therapy Care Cascade Among HIV-Positive Female Sex Workers in Mombasa, Kenya. J Acquir Immune Defic Syndr. 76(1):74-81.

Leung SS, Parumasivam T, Gao FG, Carrigy NB, Vehring R, Finlay WH, Morales S, Britton WJ, Kutter E, Chan HK. (2017) Effects of storage conditions on the stability of spray dried, inhalable bacteriophage powders. Int J Pharmaceutics 521(1-2):141-149(ePub, Feb 3, 2017).

Lipworth, W., Kerridge, I., Ioannidis, J.P.A., Mason, P.H. (2017) Ethics and Epistemology in Big Data Research. J Bioeth Inq. 14(4):489-500.

MacLennan C, Msefuka C, Gondwe EN, Gilchrist JJ, Pensulo P, Mandala WL, Mwimaniwa G, Banda M, Kenny J, Wilson LK, Phiri A, MacLennan JM, Molyneux EM, Molyneux ME, Graham SM. (2017) Presentation of life-threatening invasive nontyphoidal Salmonella disease in Malawian children: a prospective observational study. PLoS Negl Trop Dis. 11:e0006027 

Mai TQ, Van Anh NT, Hien NT, Lan NH, Giang DC, Hang PTT, Lan NTN, Marais BJ, Sintchenko V. (2017) Drug resistance and Mycobacterium tuberculosis strain diversity in TB/HIV co-infected patients in Ho Chi Minh city, Vietnam. J Glob Antimicrob Resist. 10:154-160.

Marais BJ, Becerra MC Mortality among children diagnosed with tuberculosis: Systematic review and meta-analysis. Lancet Infect Dis 2017; 17: 285-95

Marais BJ,  Heemskerk AD, Marais S, van Crevel R, Rohlwink U, Caws M, Meintjes G, Misra UK, Nguyen THM, Ruslami R, Seddon JA, Solomons R, van Toorn R, Figaji A, McIlleron H, Aarnoutse R, Schoeman J, Wilkinson RJ, Thwaites G. (2017) Standardized Methods for Enhanced Quality and Comparability of Tuberculous Meningitis studies. Clin Infect Dis. 64: 501-9

Marais, B.J., Sintchenko, V.. Epidemic spread of multidrug-resistant tuberculosis in China. Lancet Infect Dis 2017; 17: 238-9

Marais, B.J. (2017). Childhood tuberculosis – out of the shadows. BMC Pneumonia 2016; 8: 22-3

Marais, B.J. Improving access to tuberculosis preventive therapy and treatment for children. Int J Infect Dis 2017. 56: 122-5

Marais, B.J. The global tuberculosis situation and the inexorable rise of drug-resistant disease. Adv Drug Delivery Rev 2016; 102: 3-9

Marais BJ, Heemskerk AD, Marais SS, van Crevel R, Rohlwink U, Caws M, Meintjes G, Misra UK, Mai NTH, Ruslami R, Seddon JA, Solomons R, van Toorn R, Figaji A, McIlleron H, Aarnoutse R, Schoeman JF, Wilkinson RJ, Thwaites GE. (2017) Standardized Methods for Enhanced Quality and Comparability of Tuberculous Meningitis Studies:.Tuberculous Meningitis International Research Consortium. Clin Infect Dis. 15;64(4):501-509

Marais BJ, Graham SM. (2017) Symptom-based screening of child TB contacts: defining 'symptomatic'. Int J Tuberc Lung Dis. 21(7):832-833.

Marais BJ, Walker TM, Cirillo DM, Raviglione M, Abubakar I, van der Werf MJ, Boehme C, Niemann S, Castro KG, Zumla A, Sintchenko V, Crook DW. (2017) Aiming for zero tuberculosis transmission in low-burden countries. Lancet Respir Med. 5(11):846-848.

Mason, P.H., Kerridge, I., Lipworth, W. (2017). The Global in Global Health is not a Given, American Journal of Tropical Medicine and Health, 96(4), 767–769. doi:10.4269/ajtmh.16-0791.

Mason, P.H., Roy, A., Singh, P. (In Press). Reciprocity-building and the importance of interdisciplinary collaboration in tuberculosis research. Journal of Biosocial Science

Mason, P.H., Snow, K., Asugeni, R., Massey, P.D., Viney, K. (2017). Tuberculosis and Gender in the Asia-Pacific Region. Australian & New Zealand Journal of Public Health. 

McBryde E, Meehan MT, Doan TN, Ragonnet R, Marais BJ, Guernier V, Trauer J. The risk of global epidemic replacement with drug resistant M. tuberculosis strains. Int J Infect Dis 2017; 56: 14-20

McBryde, E.S., Meehan, M.T., Doan, T.N, (2017). The risk of global epidemic replacement with drug resistant M. tuberculosis strains. Int J Infect Dis.

Moyo N, Trauer J,Trevan P, Baker AM, Musemburi J, McGrath K, Nolan A, McIntyre E, Hulls J, Denholm JT.Tuberculosis screening in an aged care residential facility in a low-incidence setting. Commun Dis Intell Q Rep. 2017 Sep 1;41(3):E209-E211.

Nagalingam, G,. Vinuesa, C.G, Britton, W.J, Saunders, B.M. (2017). Modulation of Roquin function in myeloid cells reduces Mycobacterium tuberculosis induced inflammation. J. Immunology. J Immunol. 199(5):1796-1804. doi: 10.4049/jimmunol.1602069.

Nguyen, T.K.P, Tran, T.H., Nguyen, D.V., Tran, M.D., Graham SM, Marais BJ. (2017). Disease spectrum and management of children admitted with acute respiratory infection in Viet Nam. Trop Med Int Health; In press

Nguyen, T.K.P., Tran, T.H., Robert, C.L., Fox, G., Graham, S.M., Marais BJ. (2017). Risk factors for child pneumonia - focus on the Western Pacific Region. Ped Resp Rev; 21: 95-101

Nguyen T.K.P, Tran T.H., Robert C.L., Graham S.M., Marais B.J. (2017). Child pneumonia - focus on the Western Pacific Region. Ped Resp Rev; 21: 102-110

Nguyen PTK, Nguyen NV, Phung TD, Marais B. (2017) X-pert MTB/RIF® Diagnosis of Twin Infants with Tuberculosis in Da Nang, Viet Nam. J Clin Med. 6(10). pii: E96.]

Nguyen TKP, Tran TH, Pham HV, Tu L, Graham SM, Marais BJ. (2017) Encouraging rational antibiotic use in childhood pneumonia - focus on the Western Pacific region and Vietnam. BMC Pneumonia. 9:7. 

Oliwa J.N., Marais B.J. (2017) Vaccines to prevent pneumonia in children - a developing country perspective. Paediatr Respir Rev. 22:23-30.

Outhred A, Britton P, Marais BJ. (2017) Transmission of drug-resistant tuberculosis and its impact on children. J Infect. 74 Suppl 1:S128-S135

Parumasivam T, Leung SS, Tang P, Mauro C, Britton W, Chan HK. (2017) The Delivery of High-Dose Dry Powder Antibiotics by a Low-Cost Generic Inhaler. AAPS J. 19(1):191-202.

Parumasivam T, Ashhurst AS, Nagalingam G, Britton WJ, Chan HK. (2017) Inhalation of Respirable Crystalline Rifapentine Particles Induces Pulmonary Inflammation. Mol Pharm. 14(1):328-335.

Palendira, U., Parumasivam T, A.S. Ashhurst, G. Nagalingam, W.J. Britton, H. K. Chan. (2017) Inhalation of Respirable Crystalline Rifapentine Particles Induces Pulmonary Inflammation. Molecular Pharmaceutics Jan 3;14(1):328-335. 

Perez-Velez CM, Roya-Pabon CL, Marais BJ. (2017) A systematic approach to diagnosing intra-thoracic tuberculosis in children. J Infect. 74 Suppl 1:S74-S83.

Petersen, E., Khamis, F., Migliori, G.B., Bay, J.G., Marais, B., Wejse, C., Zumla, A. (2017). De-isolation of patients with pulmonary tuberculosis after start of treatment – clear, unequivocal guidelines are missing. Int J Infect Dis; 56: 34-8

Petersen E, Maeurer M, Marais B, Migliori GB, Mwaba P, Ntoumi F, Vilaplana C, Kim K, Schito M, Zumla A. World TB Day 2017: Advances, Challenges and Opportunities in the “End-TB” Era. Int J Infect Dis; 56: 1-5

Phuong NTK, Hoang TT, Van PH, Tu L, Graham SM, Marais BJ. (2017) Encouraging rational antibiotic use in childhood pneumonia: a focus on Vietnam and the Western Pacific Region. Pneumonia (Nathan). 9:7.

Quan, D., Nagalingam, G., Payne, R., Triccas, J.A. (2017). New tuberculosis drug leads from naturally occurring compounds. Int J Infect Dis. 56:212-220.

Ragonnet R, Trauer JM, Denholm JT, Marais BJ, McBryde ES. (2017) High Rates of Multidrug-Resistant and Rifampicin-Resistant Tuberculosis among Re-Treatment Cases: Where do they Come from? BMC Infect Dis; 17:36

Ragonnet R, Trauer JM, McBryde ES, Houben R, Denholm JT, Handel A, Sumner T. (2017). Is IPT more Effective in High Burden Settings? Modelling the Effect of TB Incidence on IPT Impact. Int J TB Lung Dis;21(1):60-66 .

Ragonnet R, Trauer JM, Denholm JT, Marais BJ, McBryde ES. (2017) A user-friendly mathematical modelling web interface to assist local decision making in the fight against drug-resistant tuberculosis. BMC Infect Dis. 17(1):374.

Ragonnet R, Trauer JM, Scott N, Meehan MT, Denholm JT, McBryde ES. (2018) Optimally capturing latency dynamics in models of tuberculosis transmission. Epidemics. 21:39-47.
Scott K, Morris A, Marais BJ. (2017). Medical student use of digital learning resources. Clinical Teacher; 13: 1-5

Shaweno D, Shaweno T, Trauer JM, Denholm JT, McBryde ES. (2017). Heterogeneity of Distribution of Tuberculosis in Sheka Zone, Ethiopia: Drivers and Temporal Trends. Int J TB Lung Dis, 21(1):79-85. 

Shaweno D, Trauer JM, Denholm JT, McBryde ES (2017) A novel Bayesian geospatial method for estimating tuberculosis incidence reveals many missed TB cases in Ethiopia. BMC Infect Dis. 17(1):662.

Snow, K., Hesseling, A. C., Naidoo, P., Graham, S. M., Denholm, J., Preez, K. (2017). Tuberculosis in adolescents and young adults: epidemiology and treatment outcomes in the Western Cape. INT J Tuberc Lung Dis 21(6):000–000

Tha Alene, K.A., Viney, K., McBryde, E.S., Clements, A.C. (2017). Spatial patterns of multidrug resistant tuberculosis and relationships to socio-economic, demographic and household factors in northwest Ethiopia. PloS one; 12(2).

Thirunavukkarasu S, Plain KM, de Silva K, Marais BJ, Whittington RJ. (2017) Applying the One Health concept to mycobacterial research – overcoming parochialism. Zoonoses and Public Health. 64:401-422.

Tramontana, A., Leslie, D., Nolan, A., Globan, M., Fyfe, J., Denholm, J.T, Guy, S. Cure of Pulmonary XDR TB in Melbourne: Local control of a global health challenge. Med J Aust, March 2017.

Tran, A.T., Watson, E.E., Pujari, V., Conroy, T., Dowman, L.J., Giltrap, A.M., Pang, A., Wong, W-R, Linington, R.G., Mahapatra, S., Saunders, J., Charman, S.A., West, N.P., Bugg, T.D.H, Tod, J., Dowson, C.G., Roper, D.I, Crick, D.C., Britton, W.J., Payne, R.J. (2017). Synthesis of Sansanmycin Natural Product Analogues as Potent and Selective Anti-Mycobacterials that Inhibit Lipid I Biosynthesis. Nature Communications 8:14414. 

Tod, J., Dowson, C.G., Roper, D.I, Crick, D.C., Britton, W.J., Payne, R.J. (2017). Synthesis of Sansanmycin Natural Product Analogues as Potent and Selective Anti-Mycobacterials that Inhibit Lipid I Biosynthesis. Nature Communications 8:14414.

Williams J, Mayes C, Komesaroff P, Kerridge I, Lipworth W. (2017) Conflicts of interest in medicine: taking diversity seriously. Intern Med J. 47(7):739-746.


Petersen E, Maeurer M, Marais B, Migliori GB, Mwaba P, Ntoumi F, Vilaplana C, Kim K, Schito M, Zumla A. World TB Day 2017: Advances, Challenges and Opportunities in the “End-TB” Era. Int J Infect Dis 2017; 56: 1-5


Marais BJ. Improving access to tuberculosis preventive therapy and treatment for children. Int J Infect Dis 2017. 56: 122-5


Zumla A, Schito M, Chakaya J, Marais B,  Mwaba P,  Migliori GB, Hoelscher M, Maeurer M,  Wallis RS. World TB Day 2016 - Reflections on the global TB emergency. Lancet Resp Med 2016; 4: 249-51

Hill-Cawthorne G, Marais BJ. Zika virus – brief overview. Springer Nature 2016. March 29.… @SpringerNature

Scientific letters


Marais BJ, …Standardized methods for enhanced quality and comparability of tuberculous meningitis studies – in reply. Clin Infect dis 2017: In press


Marais BJ, Graham S. Symptom-based screening of child TB contacts – defining “symptomatic”.  Int J Tuberc Lung Dis 2017; In press


Fox GJ, Dobler C, Marais BJ, Denholm J. Preventive therapy for latent tuberculosis infection – In reply. Int J Infect Dis 2017; E-pub ahead of print

Fox GJ, Dobler CC, Marais BJ, Denholm JT. (2017) Response to: Socio-political prescriptions for latent tuberculosis infection are required to prevent reactivation of tuberculosis. Int J Infect Dis. 58:117-118.

Marais BJ, Heemskerk D, Thwaites GE. (2017) Reply to Dhawan and Sankhyan: Tuberculous Meningitis International Research Consortium. Clin Infect Dis.64(12):1805.

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